Yazar "Durdağı, Serdar" için listeleme
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Design and synthesis of novel caffeic acid phenethyl ester (CAPE) derivatives and their biological activity studies in glioblastoma multiforme (GBM) cancer cell lines
Onur Sucu, Bilgesu; Koç, Elif Beyza; Şavluğ İpek, Özgecan; Mirat, Afranur; Almas, Furkan; Güzel, Melike Aybala; Doğan, Berna; Uludağ, Damla; Karakaş, Nihal; Durdağı, Serdar; Güzel, Mustafa (Elsevier Inc., 2022)Glioblastoma Multiforme (GBM) is the most aggressive brain tumor and classified as one of the deadliest cancers. The current treatment plans for GBM remains to be ineffective because of its rapid progress and inability of ... -
Instant determination of the artemisinin from various Artemisia annua L. extracts by LC-ESI-MS/MS and their in-silico modelling and in vitro antiviral activity studies against SARS-CoV-2
Doğan, Kübra; Erol, Ebru; Orhan, Müge Didem; Değirmenci, Zehra; Kan, Tuğçe; Güngör, Ayşen; Yaşa, Belkıs; Avşar, Timuçin; Çetin, Yüksel; Durdağı, Serdar; Güzel, Mustafa (Wiley, 2022)Introduction Numerous efforts in natural product drug development are reported for the treatment of Coronavirus. Based on the literature, among these natural plants Artemisia annua L. shows some promise for the treatment ... -
Mechanistic insight into the impact of a bivalent ligand on the structure and dynamics of a GPCR oligomer
Mansoor, Samman; Kayık, Gülru; Durdağı, Serdar; Şensoy, Özge (Elsevier B.V., 2022)Development of effective bivalent ligands has become the focus of intensive research toward modulation of G protein-coupled receptor (GPCR) oligomers, particularly in the field of GPCR pharmacology. Experimental studies ... -
The neutralization effect of montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies
Durdağı, Serdar; Avşar, Timuçin; Orhan, Müge Didem; Serhatlı, Müge; Balcıoğlu, Bertan Koray; Öztürk, Hasan Ümit; Kayabölen, Alişan; Çetin, Yüksel; Aydınlık, Şeyma; Bağcı-Önder, Tuğba; Tekin, Şaban; Demirci, Hasan; Güzel, Mustafa; Akdemir, Atilla; Çalış, Şeyma; Oktay, Lalehan; Tolu, İlayda; Bütün, Yaşar Enes; Erdemoğlu, Ece; Olkan, Alpsu; Tokay, Nurettin; Işık, Şeyma; Özcan, Ayşenur; Acar, Elif; Büyükkılıç, Şehriban; Yumak, Yeşim (Cell Press, 2022)Small molecule inhibitors have previously been investigated in different studies as possible therapeutics in the treatment of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In the current drug repurposing ...